Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …
the biomedical community to action—to uncover and develop antiviral interventions. One …
Drug repurposing for antimicrobial discovery
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
Infectious Diseases Society of America Guidelines on the treatment and management of patients with coronavirus disease 2019 (COVID-19)
Background There are many pharmacologic therapies that are being used or considered for
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …
[HTML][HTML] In silico prediction of potential inhibitors for the main protease of SARS-CoV-2 using molecular docking and dynamics simulation based drug-repurposing
Background The rapidly enlarging COVID-19 pandemic caused by the novel SARS-corona
virus-2 is a global public health emergency of an unprecedented level. Unfortunately no …
virus-2 is a global public health emergency of an unprecedented level. Unfortunately no …
Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID‐19
B Damle, M Vourvahis, E Wang… - Clinical …, 2020 - Wiley Online Library
Azithromycin (AZ) is a broad‐spectrum macrolide antibiotic with a long half‐life and a large
volume of distribution. It is primarily used for the treatment of respiratory, enteric, and …
volume of distribution. It is primarily used for the treatment of respiratory, enteric, and …
[HTML][HTML] Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for
COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2 …
COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2 …
[HTML][HTML] FDA-approved drugs with potent in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2
(1) Background: Drug repositioning is an unconventional drug discovery approach to
explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue …
explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
Drug combination therapy increases successful drug repositioning
Highlights•Publications for drug repositioning have drastically increased in past five
years.•Different types of drug repositioning and available resources have been …
years.•Different types of drug repositioning and available resources have been …
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …
and its link to microcephaly and other neurological conditions, we performed a drug …