NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective

M Alrouji, HM Al‐kuraishy, AI Al‐Gareeb… - Journal of Cellular …, 2023 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease (AD). Genetic predisposition and immune dysfunction are involved in …

Multifunctional role of natural products for the treatment of Parkinson's disease: at a glance

MM Rahman, X Wang, MR Islam, S Akash… - Frontiers in …, 2022 - frontiersin.org
Natural substances originating from plants have long been used to treat neurodegenerative
disorders (NDs). Parkinson's disease (PD) is a ND. The deterioration and subsequent …

[HTML][HTML] Association between Parkinson's disease and diabetes mellitus: From epidemiology, pathophysiology and prevention to treatment

H Yu, T Sun, X He, Z Wang, K Zhao, J An… - Aging and …, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) and Parkinson's disease (PD) are both age-related diseases of
global concern being among the most common chronic metabolic and neurodegenerative …

[HTML][HTML] Glucose metabolism impairment in Parkinson's disease

C Dai, C Tan, L Zhao, Y Liang, G Liu, H Liu… - Brain Research …, 2023 - Elsevier
Impairments in systematic and regional glucose metabolism exist in patients with
Parkinson's disease (PD) at every stage of the disease course, and such impairments are …

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

E Studzińska-Sroka, M Bulicz, M Henkel, N Rosiak… - Molecules, 2023 - mdpi.com
Evernia prunastri is a lichen widely distributed in the Northern Hemisphere. Its biological
properties still need to be discovered. Therefore, our paper focuses on studies of E. prunastri …

Update to the treatment of Parkinson's disease based on the gut-brain axis mechanism

X Sun, L Xue, Z Wang, A Xie - Frontiers in neuroscience, 2022 - frontiersin.org
Gastrointestinal (GI) symptoms represented by constipation were significant non-motor
symptoms of Parkinson's disease (PD) and were considered early manifestations and …

Evaluation of type 1 diabetes mellitus as a risk factor of Parkinson's disease in a Drosophila model

FJ Sanz, G Martínez‐Carrión… - … Zoology Part A …, 2023 - Wiley Online Library
Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood glucose
levels, resulting from insulin dysregulation. Parkinson's disease (PD) is the most common …

Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming

KS Lee, SH Yoon, I Hwang, JH Ma, E Yang… - Journal of …, 2024 - Springer
Hyperglycemia has been shown to modulate the immune response of peripheral immune
cells and organs, but the impact of hyperglycemia on neuroinflammation within the brain …

RGS10 mitigates high glucose-induced microglial inflammation via the reactive oxidative stress pathway and enhances synuclein clearance in microglia

J Chung, J Jernigan, KB Menees… - Frontiers in Cellular …, 2024 - frontiersin.org
Microglia play a critical role in maintaining brain homeostasis but become dysregulated in
neurodegenerative diseases. Regulator of G-protein Signaling 10 (RGS10), one of the most …

Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal …

S Lapmanee, S Bhubhanil, P Wongchitrat… - Pharmaceutics, 2024 - mdpi.com
Diabetic Parkinson's disease (DP) is a progressive neurodegenerative disease with
metabolic syndrome that is increasing worldwide. Emerging research suggests that …