[HTML][HTML] Clonal hematopoiesis: Mutation-specific adaptation to environmental change
MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
Flow cytometric findings in clonal cytopenia of undetermined significance
P Nirmalanantham, R Sakhi, R Beck… - American Journal of …, 2022 - academic.oup.com
Objectives To examine flow cytometric (FCM) findings in clonal cytopenia of undetermined
significance (CCUS) in relation to variant allele fraction (VAF) and mutation risk. Methods …
significance (CCUS) in relation to variant allele fraction (VAF) and mutation risk. Methods …
[HTML][HTML] Clonal hematopoiesis: a shared risk factor for cardiovascular diseases and tumors
LF Zha, X Cheng - Oncology and Translational Medicine, 2024 - journals.lww.com
Clonal hematopoiesis (CH) is a clonally expanded population of hematopoietic stem cells
carrying somatic mutations that differentiate through multilineage hematopoiesis to form …
carrying somatic mutations that differentiate through multilineage hematopoiesis to form …
A holistic understanding of cancer genomics to inform treatment and research
PSW Tsai - 2020 - researchspace.auckland.ac.nz
Background: The increase in volume of cancer genomic data has improved our
understanding of cancer biology as well as laying the foundation for clinical precision …
understanding of cancer biology as well as laying the foundation for clinical precision …
骨髄異形成症候群のエピゲノム異常と新規治療法開発
國本博義 - 臨床血液, 2024 - jstage.jst.go.jp
抄録 エピゲノムは DNA のメチル化やヒストンタンパク質のメチル化, アセチル化, リン酸化,
ユビキチン化などの化学的修飾を介してゲノム機能やクロマチン構造の改変をもたらし …
ユビキチン化などの化学的修飾を介してゲノム機能やクロマチン構造の改変をもたらし …
骨髄異形成症候群と関連する免疫病態と治療
中島秀明 - 臨床血液, 2023 - jstage.jst.go.jp
抄録 骨髄異形成症候群 (myelodysplastic syndromes, MDS) は造血幹細胞のゲノム変異を基盤
に発症するクローン性造血不全であり, 血球減少を主徴とする低リスク MDS と白血病への進展を …
に発症するクローン性造血不全であり, 血球減少を主徴とする低リスク MDS と白血病への進展を …