Contraction of smooth muscle is regulated by the cytosolic Ca2+ level ([Ca2+] i) b, and the
sensitivity to Ca2+ of the contractile elements in response to changes in the environment …

Smooth muscle myosin light chain kinase (MLCK) plays a crucial role in artery contraction,
which regulates blood pressure and blood flow distribution. In addition to this role, MLCK …

Not much is known about the mobility of synaptic vesicles inside small synapses of the
central nervous system, reflecting a lack of methods for visualizing these dynamics. We …

Using the specific antibodies pLC1 and pLC2 for mono-and diphosphorylated 20-kDa
myosin light chain (MLC20) at Ser19 and at both Thr18 and Ser19, respectively, we …

Protein phosphorylation and dephosphorylation mediated by protein kinases and protein
phosphatases, respectively, represent essential steps in a variety of vital neuronal …

Staurosporine analogs, whose γ-lactam functionality was converted into γ-lactone, were
synthesized. The key step involves remarkably efficient ring-opening and then …

The present study was designed to determine the role of protein kinase C (PKC) in the
myogenic response of small arteries. In particular, we tested whether inhibition of PKC …

We investigated the effects of ML-9 [1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1, 4-
diazepine], a myosin light chain kinase (MLCK) inhibitor, on intracellular Ca2+ concentration …

Calmodulin (CaM)-regulated protein kinases have provided insight into the regulatory
mechanisms that underlie Ca” signal transduction through calmodulin. Specifically …

Protein kinase C (PKC) activation by a phorbol ester increases myosin light chain (MLC 20)
phosphorylation through inhibition of MLC phosphatase (MLCP) and enhances contraction …