Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …

Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

Enabled by a plethora of new technologies, research in membrane transporters has
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …

There are over 70 known lysosomal storage disorders (LSDs), most caused by mutations in
genes encoding lysosomal hydrolases. Central nervous system involvement is a hallmark of …

The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …

Lysosomes are degradative organelles in eukaryotic cells mediating the hydrolytic
catabolism of various macromolecules to small basic building blocks. These low‐molecular …

Dysfunction of the endolysosomal system is often associated with neurodegenerative
disease because postmitotic neurons are particularly reliant on the elimination of …

The regulation of luminal ion concentrations is critical for the function of, and transport
between intracellular organelles. The importance of the acidic pH in the compartments of the …

Amino acid transporters are expressed in mammalian cells not only in the plasma
membrane but also in intracellular membranes. The conventional function of these …