Despite significant advances in developing drugs to treat brain tumours, achieving
therapeutic concentrations of the drug at the tumour site remains a major challenge due to …

ABSTRACT Preclinical Research Psychosis remains one of the most challenging health
problems for society, affecting hundreds of millions of people worldwide. Although current …

Schizophrenia is one of the top 25 causes of global diseases burdens in terms of years lived
with the disease and the emotional and economical strains it imposes on the society …

Psychosis is a high-incidence pathology associated with a profound alteration in the
perception of reality. The limitations of drugs available on the market have stimulated the …

Background: Quetiapine fumarate, a 2nd generation anti-psychotic drug has oral
bioavailability of 9% because of hepatic first pass metabolism. Reports suggest that co …

Quetiapine (QTP) has been known to suppress cancer progression in patients suffering from
mental disorders. This study aimed to produce the folate-linked chitosan-coated …

This study aims to develop quetiapine (QTP)-loaded β-cyclodextrin (β-CD) based co-
polymeric thiolated polyethylene glycol-poly (lactic-co-glycolic acid)(t-PEG-PLGA) …

Alzheimer's disease (AD) is a neurodegenerative disease that affects a wide range of
populations and is the primary cause of death in various countries. The treatment of AD is …

Background: Conventional administration of chemotherapeutic agents associated with low
drug distribution to cancer cells with multiple systemic toxicities. Thus, enhancing the active …

Quetiapine fumarate has possessed low solubility and extremely poor bioavailability, which
restricts its oral administration. In order to address this concern, microemulsification …