Three topics affecting cobalamin, folate, and homocysteine that have generated interest,
activity, and advances in recent years are discussed. These are:(I) the application of an …

As many as one-third of mutations in a gene result in the corresponding enzyme having an
increased Michaelis constant, or K m,(decreased binding affinity) for a coenzyme, resulting …

Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for
atherosclerosis and vascular disease. Homocysteine is a branch‐point intermediate of …

Derivatives of cobalamin (vitamin B12) are required for activity of two enzymes in humans.
Adenosylcobalamin is required for activity of mitochondrial methylmalonylCoA mutase and …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Sulfur containing amino acids contribute substantially to the maintenance and integrity of
cellular systems by influencing cellular redox state and cellular capacity to detoxify toxic …

Methionine synthase is a key enzyme in the methionine cycle that catalyzes the
transmethylation of homocysteine to methionine in a cobalamin-dependent reaction that …

Cobalamin deficiency in the newborn usually results from cobalamin deficiency in the
mother. Megaloblastic anaemia, pancytopenia and failure to thrive can be present …

Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …