The disruption of blood–brain barrier (BBB) for multiple sclerosis (MS) pathogenesis has a
double effect: early on during the onset of the immune attack and later for the CNS self …

Cholesterol is an essential component of all cell membranes and particularly enriched in
myelin membranes. Myelin membranes are a major target of immune attacks in the chronic …

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …

Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain
cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate …

The gut microbiota is involved in the development of the immune system and can modulate
the risk for immune-mediated disorders such as multiple sclerosis (MS). Dysbiosis has been …

Why can we still not translate preclinical research to clinical treatments for acute strokes?
Despite> 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two …

Microbiota-derived metabolites are important molecules connecting the gut to the brain.
Over the last decade, several studies have highlighted the importance of gut-derived …

CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with
disease progression, but the pathogenic role and antigenic targets of these clonally …

Autoimmune central nervous system (CNS) demyelinating diseases are a major public
health burden and poorly controlled by current immunosuppressants. More precise …

Therapy for relapsing–remitting multiple sclerosis (MS) has advanced dramatically despite
incomplete understanding of the cause of the condition. Current treatment involves inducing …