Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes

Y Wang, S Wu, Q Li, H Sun, H Wang - Advanced Science, 2023 - Wiley Online Library
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Ferroptosis-regulated cell death as a therapeutic strategy for neurodegenerative diseases: current status and future prospects

JB Zhang, X Jia, Q Cao, YT Chen, J Tong… - ACS chemical …, 2023 - ACS Publications
Ferroptosis is increasingly being recognized as a key element in the pathogenesis of
diverse diseases. Recent studies have highlighted the intricate links between iron …

Berberine ameliorates iron levels and ferroptosis in the brain of 3× Tg-AD mice

X Li, J Chen, W Feng, C Wang, M Chen, Y Li, J Chen… - Phytomedicine, 2023 - Elsevier
Background Berberine (BBR) is a natural alkaloid extracted from the herb Coptis chinensis.
This compound has the ability to penetrate the blood-brain barrier (BBB) and exhibit …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies

N Zhang, J Nao, X Dong - Journal of Agricultural and Food …, 2023 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that
occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and …

Dendrobine rescues cognitive dysfunction in diabetic encephalopathy by inhibiting ferroptosis via activating Nrf2/GPX4 axis

YS Shi, JC Chen, L Lin, YZ Cheng, Y Zhao, Y Zhang… - Phytomedicine, 2023 - Elsevier
Background Ferroptosis playsa crucial role in the development of dementia and dendrobine
(Den) possesseshypoglycemic and neuroprotective effects. However, the character of …

The role of cellular defense systems of ferroptosis in Parkinson's disease and Alzheimer's disease

J Chu, J Li, L Sun, J Wei - International Journal of Molecular Sciences, 2023 - mdpi.com
Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common rapidly
developing neurodegenerative diseases that lead to serious health and socio-economic …

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

N Živanović, M Lesjak, N Simin, SKS Srai - Antioxidants, 2024 - mdpi.com
Ferroptosis is a recently discovered type of programmed cell death that is mechanistically
different from other types of programmed cell death such as apoptosis, necroptosis, and …

Prophylactic effects of apigenin against hyperglycemia-associated amnesia via activation of the Nrf2/ARE pathway in zebrafish

B Haridevamuthu, SPRR Nayak, R Murugan… - European Journal of …, 2024 - Elsevier
The escalating focus on ageing-associated disease has generated substantial interest in the
phenomenon of cognitive impairment linked to diabetes. Hyperglycemia exacerbates …

Danggui Buxue Tang improves therapeutic efficacy of doxorubicin in triple negative breast cancer via ferroptosis

G Gong, K Ganesan, Y Liu, Y Huang, Y Luo… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Danggui Buxue Tang (DBT) has been used for
over 800 years to enhance Qi and nourish Blood, and it is particularly beneficial for cancer …