Our aim is to identify new small molecules with antimicrobial potential, especially against
colistin-resistant (Col-R) Acinetobacter baumannii and Escherichia coli. After initial hits …

The PI3K/AKT/mTOR pathway plays critical roles in a wide array of biological processes.
Phosphatidylinositol 3-kinase gamma (PI3Kγ), a class IB PI3K family member, represents a …

Reinventing approved therapeutic proteins for a new dose, a new formulation, a new route
of administration, an improved safety profile, a new indication, or a new conjugate with a …

Ion channels play a crucial role in a variety of physiological and pathological processes,
making them attractive targets for drug development in diseases such as diabetes, epilepsy …

Our previous research has revealed phosphoglycerate kinase 1 (PGK1) enhances
tumorigenesis and sorafenib resistance of kidney renal clear cell carcinoma (KIRC) by …

Drug discovery has traditionally been a time consuming and expensive endeavor.
Additionally, drugs weren't as effectively designed as those that are being predicted and …

The accelerating growth of make-on-demand chemical libraries provides novel opportunities
to identify starting points for drug discovery with virtual screening. However, the recently …

Virtual libraries for ligand discovery have recently increased 10,000-fold, and this is thought
to have improved hit rates and potencies from library docking. This idea has not, however …

Ligand-based virtual screening is a widespread method in modern drug design. It allows for
a rapid screening of large compound databases in order to identify similar structures. Here …

Recent advancements in AI-driven technologies, particularly in protein structure prediction,
are significantly reshaping the landscape of drug discovery and development. This review …