The γ-lactam moiety is present in a large number of natural and non-natural biologically
active compounds. The range of biological activities covered by these compounds is very …

Sulfur ylides first disclosed in 1930 started to gain more attention in the 1960s, thanks mainly
to the studies by Corey and Chaykovsky on their use for the preparation of strained rings …

The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry,
and it laid the ground for the early days of target-oriented organic synthesis. 1 Since then …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the
activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1 …

We recently reported the cultivation and phylogenetic characterization of a new group of
obligate marine actinomycete bacteria that is widely distributed in ocean sediments.[1] …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex,
which degrades the majority of cellular polypeptides by an unusual enzyme mechanism …

Natural products are both a fundamental source of new chemical diversity and an integral
component of today's pharmaceutical compendium. Yet interest in natural-product drug …