Clonal hematopoiesis due to mosaic chromosomal alterations: Impact on disease risk and mortality
Mosaic chromosomal alterations (mCAs) are the clonal expansion of large somatically
acquired structural chromosomal changes present on the autosomes and sex …
acquired structural chromosomal changes present on the autosomes and sex …
Determinants of mosaic chromosomal alteration fitness
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …
Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood
YA Jakubek, X Ma, AM Stilp, F Yu, J Bacon, JW Wong… - medRxiv, 2024 - medrxiv.org
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in
human blood. The presence of mLOY is associated with altered blood cell counts and …
human blood. The presence of mLOY is associated with altered blood cell counts and …
CHIP is associated with cardiovascular disease in the UK Biobank
Clonal hematopoiesis (CH) is a form of age-related somatic mosaicism. CH encompasses
both clonal events with recognizable leukemic driver mutations, such as CH of indeterminate …
both clonal events with recognizable leukemic driver mutations, such as CH of indeterminate …