Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction

Y Hou, F Fan, N Xie, Y Zhang, X Wang, X Meng - Phytomedicine, 2024 - Elsevier
Abstract Background/Purpose: Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (R.
crenulate), a famous and characteristic Tibetan medicine, has been demonstrated to exert …

The total iridoid glycoside extract of Lamiophlomis rotata Kudo induces M2 macrophage polarization to accelerate wound healing by RAS/p38 MAPK/NF-κB pathway

L Lei, G Wan, X Geng, J Sun, Y Zhang, J Wang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Lamiophlomis rotata (Benth.) Kudo (L. rotata), a
Tibetan medicinal plant, is used to treat “yellow-water diseases”, such as skin disease …

The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway

G Wan, Z Chen, L Lei, X Geng, Y Zhang, C Yang… - Chinese Medicine, 2023 - Springer
Background Hepatic fibrosis is characterized by the excessive deposition of extracellular
matrix (ECM) which is mainly secreted by activated hepatic stellate cells (HSCs) …

Traditional Chinese medicine monomers: Targeting pulmonary artery smooth muscle cells proliferation to treat pulmonary hypertension

X Yang, Y Yang, K Liu, C Zhang - Heliyon, 2023 - cell.com
Pulmonary hypertension (PH) is a complex multifactorial disease characterized by increased
pulmonary vascular resistance and pulmonary vascular remodeling (PVR), with high …

Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways

Q Liu, Q Luo, B Zhong, K Tang, X Chen, S Yang… - European Journal of …, 2024 - Elsevier
Myocardial remodeling, which occurs in the final stage of cardiovascular diseases such as
hypertension, can ultimately result in heart failure. However, the pathogenesis of myocardial …

Estrogen-like effect of Bazi Bushen capsule in ovariectomized rats

D Wang, L Chang, J Hao, J Zhang, Y Song… - JoVE (Journal of …, 2023 - jove.com
This study aims to show the estrogen-like effect of Bazi Bushen capsule (BZBS), a Chinese
herbal compound, in ovariectomized mice. Female Sprague-Dawley (SD) rats were …

Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats

XD Chen, JX Wei, HY Wang, YY Peng, C Tang… - …, 2023 - Elsevier
Post-traumatic stress disorder (PTSD) is a complex mental disorder, closely associated with
stress and traumatic events. Salidroside (Sal) has been reported to possess neuroprotective …

Zexieyin formula alleviates atherosclerosis with cognitive impairment: A novel role in the treatment of comorbidities and its underlying mechanisms

Y Sun, H Zhang, R Liu, S Xing, R Huang, D Di… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevancy Zexieyin formula (ZXYF) has been identified to have
therapeutic actions of atherosclerosis (AS). It's unknown that whether ZXYF has therapeutic …

Detection of CD40 Protein-Umbelliferone Interaction via Differential Scanning Fluorescence

N Cairang, Y Zhang, H Jiang, T Sonan… - JoVE (Journal of …, 2024 - jove.com
The investigation of interactions between different molecules is a crucial aspect of
understanding disease pathogenesis and screening for drug targets. Umbelliferone, an …

Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells

C Song, Z Chu, J Dai, D Xie, T Qin, L Xie, Z Zhai… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Moschus, first described in the Shennong's Classic of the
Materia medicine, is a scarce and precious animal medicine. Modern pharmacological …