Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

S Waheed, Z Li, F Zhang, A Chiarini, U Armato… - Journal of …, 2022 - Springer
The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel
solutions potentially capable of revolutionizing health care by improving efficacy …

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of Nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

Sodium alginate—natural microencapsulation material of polymeric microparticles

OD Frent, LG Vicas, N Duteanu, CM Morgovan… - International Journal of …, 2022 - mdpi.com
From the multitude of materials currently available on the market that can be used in the
development of microparticles, sodium alginate has become one of the most studied natural …

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

The application of exosomes and exosome-nanoparticle in treating brain disorders

S Salarpour, M Barani, A Pardakhty, M Khatami… - Journal of Molecular …, 2022 - Elsevier
Brain-derived exosomes (BDEs) are extracellular nanovesicles released by all central
nervous system cell lineages and contain cargo from the cells that produced them. In …

Modulation of gut barrier functions in ulcerative colitis by hyaluronic acid system

NG Kotla, ILM Isa, S Rasala, S Demir… - Advanced …, 2022 - Wiley Online Library
The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are
associated with superficial mucosal damage and intermittent wounding that leads to …

Multicomponent System of Single‐Walled Carbon Nanotubes Functionalized with a Melanin‐Inspired Material for Optical Detection and Scavenging of Metals

V Wulf, E Bichachi, A Hendler‐Neumark… - Advanced Functional …, 2022 - Wiley Online Library
The accumulation of metal ions in organisms and the presence of heavy metals in water
cause adverse effects on ecosystems and results in numerous human health issues such as …

[HTML][HTML] Tiered testing of micro-and nanoplastics using intestinal in vitro models to support hazard assessments

G Bredeck, B Halamoda-Kenzaoui, A Bogni… - Environment …, 2022 - Elsevier
The uncertainty of potential risks associated with micro-and nanoplastics (MNPs) are of
growing public concern. However, the diversity of MNPs in the environment makes a …

Chitooligosaccharide reconstitutes intestinal mucus layer to improve oral absorption of water-soluble drugs

Y Qi, M Jin, Q Li, Q Wu, Z Liao, M Wei, X Fan… - Journal of Controlled …, 2023 - Elsevier
Intestinal mucus is a complex natural hydrogel barrier with unique physical properties that
impede the absorption of various oral drugs. Both washout from the upper water layer and …

Mechanisms of uptake and transport of particulate formulations in the small intestine

L Delon, RJ Gibson, CA Prestidge, B Thierry - Journal of Controlled …, 2022 - Elsevier
Micro-and nano-scale particulate formulations are widely investigated towards improving the
oral bioavailability of both biologics and drugs with low solubility and/or low intestinal …