Developmental patterning is essential for regulating cellular events such as axial patterning,
segmentation, tissue formation, and organ size determination during embryogenesis …

Intestinal microbiota is a unique ecosystem, known as the" second genome" of human
beings. With the widespread application of next generation sequencing (NGS), especially 16 …

The serine/threonine kinase AKT is a central node in cell signaling. While aberrant AKT
activation underlies the development of a variety of human diseases, how different patterns …

Spinal cord injury (SCI) is a debilitating condition that results in significant impairment of
motor function and sensation. Despite the ongoing efforts to develop effective treatments …

Background: Alzheimer disease (AD) is a degenerative brain disease, which may lead to
severe memory loss and other cognitive disorders. However, few effective drugs are …

Objectives Jiao-tai-wan (JTW) has been often used to treat insomnia and diabetes mellitus.
Recent studies found its antidepressant activity, but the related mechanism is not clear. This …

Optogenetics, utilising light-reactive proteins to manipulate tissue activity, are a relatively
novel approach in the field of cardiac electrophysiology. We here provide an overview of …

BRG1 is a key factor in the process of apoptosis and oxidative damage; however, its role in
the pathophysiology of ischemic stroke is unclear. Here, we discovered that during middle …

Alzheimer's disease (AD) is an extremely prevalent neurodegenerative disease. Long
noncoding RNAs (lncRNAs) play pivotal roles in the regulation of AD. However, the function …

Dementia is a syndrome that impairs learning and memory. To date, there is no effective
therapy for dementia. Current prescription drugs, such as cholinesterase inhibitors, fail to …