[HTML][HTML] Bioelectricity in developmental patterning and size control: evidence and genetically encoded tools in the zebrafish model
MR Silic, GJ Zhang - Cells, 2023 - mdpi.com
Developmental patterning is essential for regulating cellular events such as axial patterning,
segmentation, tissue formation, and organ size determination during embryogenesis …
segmentation, tissue formation, and organ size determination during embryogenesis …
[HTML][HTML] The mechanism of intestinal microbiota regulating immunity and inflammation in ischemic stroke and the role of natural botanical active ingredients in …
J Zeng, K Yang, H Nie, L Yuan, S Wang, L Zeng… - Biomedicine & …, 2023 - Elsevier
Intestinal microbiota is a unique ecosystem, known as the" second genome" of human
beings. With the widespread application of next generation sequencing (NGS), especially 16 …
beings. With the widespread application of next generation sequencing (NGS), especially 16 …
[HTML][HTML] An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
The serine/threonine kinase AKT is a central node in cell signaling. While aberrant AKT
activation underlies the development of a variety of human diseases, how different patterns …
activation underlies the development of a variety of human diseases, how different patterns …
[HTML][HTML] The discovery of the new mechanism: celastrol improves spinal cord injury by increasing cAMP through VIP-ADCYAP1R1-GNAS pathway
C Li, W Shen, Z Xu, C Li, Q Liu, Y Pang, J Li… - Biomedicine & …, 2023 - Elsevier
Spinal cord injury (SCI) is a debilitating condition that results in significant impairment of
motor function and sensation. Despite the ongoing efforts to develop effective treatments …
motor function and sensation. Despite the ongoing efforts to develop effective treatments …
[HTML][HTML] A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease
X Wu, X Zheng, H Tang, L Zhao, C He, Y Zou, X Song… - Medicine, 2022 - journals.lww.com
Background: Alzheimer disease (AD) is a degenerative brain disease, which may lead to
severe memory loss and other cognitive disorders. However, few effective drugs are …
severe memory loss and other cognitive disorders. However, few effective drugs are …
[HTML][HTML] Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice
Y Tang, H Wang, K Nie, Y Gao, H Su, Z Wang… - Biomedicine & …, 2022 - Elsevier
Objectives Jiao-tai-wan (JTW) has been often used to treat insomnia and diabetes mellitus.
Recent studies found its antidepressant activity, but the related mechanism is not clear. This …
Recent studies found its antidepressant activity, but the related mechanism is not clear. This …
[HTML][HTML] Recent advances and current limitations of available technology to optically manipulate and observe cardiac electrophysiology
GA Marchal, V Biasci, P Yan, C Palandri… - … -European Journal of …, 2023 - Springer
Optogenetics, utilising light-reactive proteins to manipulate tissue activity, are a relatively
novel approach in the field of cardiac electrophysiology. We here provide an overview of …
novel approach in the field of cardiac electrophysiology. We here provide an overview of …
[HTML][HTML] BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia …
K Guo, Y Shang, Z Wang, Y Li, J Chen, B Zhu… - International …, 2023 - Elsevier
BRG1 is a key factor in the process of apoptosis and oxidative damage; however, its role in
the pathophysiology of ischemic stroke is unclear. Here, we discovered that during middle …
the pathophysiology of ischemic stroke is unclear. Here, we discovered that during middle …
LncRNA ENST00000440246. 1 Promotes Alzheimer's Disease Progression by Targeting PP2A
S Gao, C Fan, Y Wang, W Yang, H Jiang - Biochemical Genetics, 2024 - Springer
Alzheimer's disease (AD) is an extremely prevalent neurodegenerative disease. Long
noncoding RNAs (lncRNAs) play pivotal roles in the regulation of AD. However, the function …
noncoding RNAs (lncRNAs) play pivotal roles in the regulation of AD. However, the function …
[HTML][HTML] Traditional Chinese medicine promotes the control and treatment of dementia
P Tao, W Xu, S Gu, H Shi, Q Wang, Y Xu - Frontiers in Pharmacology, 2022 - frontiersin.org
Dementia is a syndrome that impairs learning and memory. To date, there is no effective
therapy for dementia. Current prescription drugs, such as cholinesterase inhibitors, fail to …
therapy for dementia. Current prescription drugs, such as cholinesterase inhibitors, fail to …