[HTML][HTML] The “Cairo accord”-towards the eradication of RHD: an update

S Kotit, DIW Phillips, A Afifi, M Yacoub - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Rheumatic heart disease (RHD) is the most common cause of acquired heart disease in
children and young adults. It continues to be prevalent in many low-and middle-income …

Early diagnosis of acute rheumatic fever and rheumatic heart disease as part of a secondary prevention strategy: Narrative review

J Bennett, NN Rentta, W Leung… - … of paediatrics and …, 2021 - Wiley Online Library
Acute rheumatic fever (ARF) and its sequela rheumatic heart disease (RHD) remain
significant causes of morbidity and mortality. In New Zealand, ARF almost exclusively affects …

Potential for molecular testing for group A Streptococcus to improve diagnosis and management in a high-risk population: a prospective study

AP Ralph, DC Holt, S Islam, J Osowicki… - Open Forum …, 2019 - academic.oup.com
Background In high-burden settings, guidelines recommend antibiotic treatment for all
suspected group A Streptococcus (GAS) infections to prevent rheumatic fever and …

An eight-plex immunoassay for Group A streptococcus serology and vaccine development

AL Whitcombe, F Han, SM McAlister… - Journal of …, 2022 - Elsevier
Abstract Group A Streptococcus (GAS) is a major human pathogen responsible for
superficial infections through to life-threatening invasive disease and the autoimmune …

Systems immunology reveals a linked IgG3–C4 response in patients with acute rheumatic fever

AW Chung, TKC Ho, P Hanson‐Manful… - Immunology and cell …, 2020 - Wiley Online Library
Acute rheumatic fever (ARF) and chronic rheumatic heart disease (RHD) are autoimmune
sequelae of a Group A streptococcal infection with significant global mortality and poorly …

Development and Evaluation of a New Triplex Immunoassay That Detects Group A Streptococcus Antibodies for the Diagnosis of Rheumatic Fever

AL Whitcombe, P Hanson-Manful, S Jack… - Journal of clinical …, 2020 - Am Soc Microbiol
Streptococcal serology is a cornerstone in the diagnosis of acute rheumatic fever (ARF), a
postinfectious sequela associated with group A Streptococcus infection. Current tests that …

Cross-sectional study of population-specific streptococcal antibody titres in Uganda

E Okello, M Murali, J Rwebembera, J Atala… - Archives of disease in …, 2020 - adc.bmj.com
Objective Despite substantial variation of streptococcal antibody titres among global
populations, there is no data on normal values in sub-Saharan Africa. The objective of this …

[HTML][HTML] Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus …

U Nakakana, A Serry-Bangura, BE Edem, P Tessitore… - Drugs in R&D, 2024 - Springer
Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can
induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and …

Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.

J Osowicki, HR Frost, KI Azzopardi, AL Whitcombe… - bioRxiv, 2024 - biorxiv.org
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded
vaccine development. To address these gaps and evaluate vaccine candidates, we …

[HTML][HTML] Utility of human immune responses to GAS antigens as a diagnostic indicator for ARF: a systematic review

MT Salie, K Rampersadh, B Muhamed… - Frontiers in …, 2021 - frontiersin.org
Background: Previous studies have established that streptococcal antibody titer is correlated
with a diagnosis of acute rheumatic fever (ARF). However, results vary in the usefulness of …