Lactate in tumors has long been considered “metabolic junk” derived from the glycolysis of
cancer cells and utilized only as a biomarker of malignancy, but is presently believed to be a …

Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

The desirable curative effect in clinical immunotherapy has been challenging due to the
immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism in …

Single-atom nanozymes (SAZs) with peroxidase (POD)-like activity have good nanocatalytic
tumor therapy (NCT) capabilities. However, insufficient hydrogen peroxide (H2O2) and …

Reactive oxygen species (ROS) play a crucial role in physiological and pathological
processes, emerging as a therapeutic target in cancer. Owing to the high concentration of …

Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor
growth, metastasis, death and other biological processes. ROS-based nanodynamic …

Given that traditional anticancer therapies fail to significantly improve the prognoses of triple
negative breast cancer (TNBC), new modalities with high efficiency are urgently needed …

Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor
elimination strategy for lung adenocarcinoma (ADC). However, the unsatisfactory Fenton …

The construction of a novel nanocarrier that can break the redox balance in tumor cell is a
promising anti‐tumor strategy. Herein, a tumor microenvironment (TME)‐responsive …

Chemodynamic therapy (CDT) has aroused extensive attention as a potent therapeutic
modality. However, its practical application is severely restricted by the strong acidity …