The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Elevation in homocysteine (Hcy) level is associated with insulin resistance; however, the
causality between them and the underlying mechanism remain elusive. Here, we show that …

Dysregulated maternal nutrition, such as vitamin deficiencies and excessive levels of
glucose and fatty acids, increases the risk for congenital heart disease (CHD) in the …

Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-
wide association studies across a range of cardiovascular traits and pathologies have …

Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease
(CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in …

Prenatal diagnosis of congenital heart disease (CHD) relies primarily on fetal
echocardiography conducted at mid‐gestational age—the sensitivity of which varies among …

Background: Folate deficiency is an independent risk factor for congenital heart disease
(CHD); however, the maternal plasma folate level is paradoxically not a good diagnostic …

Several studies showed that the genetic mutations in the folate-related enzyme genes might
be associated with male infertility; however, the results were still inconsistent. We performed …

Barker's concept of 'foetal programming'proposes that intrauterine growth restriction (IUGR)
predicts complex metabolic diseases through relationships that may be further modified by …

Congenital heart disease (CHD) is the most common birth abnormality, and more than 40%
CHD subtypes are sporadic atrial septal defect (ASD) and ventricular septal defect (VSD) …