The aim of the present study was to develop a novel dosage form of multivesicular
liposomes for oleanolic acid (OA) to overcome its poor solubility, prolong therapeutic drug …

Endoplasmic reticulum (ER) stress is a normal molecular process induced by the over-
accumulation of misfolded or unfolded proteins. ER stress induces the unfolded protein …

Doxorubicin in combination with other cytotoxic drugs has clinical advantages. However,
doxorubicin-induced cardiotoxicity negatively impacts clinical utility and outcomes …

Oleanolic acid (OA) is a well-known pentacyclic triterpenoid compound, which has been
used as a dietary supplement and is supplied as an over-the-counter drug for the treatment …

Oleanolic acid (OA) has low aqueous solubility and low permeability, which results poor
bioavailability. To surmount the inadequacy, our aim was to fabricate oleanolic acid loaded …

In this work, the soy protein/chitosan-based microsphere (SCM), as a stable biocompatible
vehicle of oleanolic acid (OA), was constructed for the first time under acidic conditions, and …

Oleanolic acid (OA) is a natural triterpenoid with anticancer properties, but its hydrophobic
nature and poor aqueous solubility pose challenges in pharmaceutical formulation …

Oleanolic acid (OA) is the main triterpenic acid of olive leaves known for numerous
pharmacological properties, including antioxidant activity. However, it is poorly soluble in …

Abstract yeyachun and danshen exist as Chinese patent medicine, Xuemai Tong, and are
clearly effective at alleviating liver fibrosis (LF). Previous studies have indicated that …