When Folkman first suggested a theory about the association between angiogenesis and
tumor growth in 1971, the hypothesis of targeting angiogenesis to treat cancer was formed …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Aberrant cytokine expression has been proposed as an underlying cause of psoriasis,
although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in …

IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte
proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma …

BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that regulate the
expression of approximately 60% of all human genes. They play important roles in …

A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of
herpesviral and poxviral members and several cellular sequence paralogs, including IL-19 …

Class II cytokine receptors were originally defined on the basis of sequence homologies in
the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and …

Cytokines that signal through Class II receptors form a distinct family that includes the
interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has …