Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Amorphous solid dispersions (ASDs) are probably the most common and important
supersaturating drug delivery systems for the formulation of poorly water-soluble …

We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …

Objectives Supersaturating formulations hold great promise for delivery of poorly soluble
active pharmaceutical ingredients (APIs). To profit from supersaturating formulations …

Objectives Drug precipitation in vivo poses a significant challenge for the pharmaceutical
industry. During the drug development process, the impact of drug supersaturation or …

Supersaturating formulations are increasingly being used to improve the absorption of orally
administered poorly water-soluble drugs. To better predict outcomes in vivo, we must be …

Solubility advantage of thermodynamically highly unstable cocrystals, which undergo
solution-mediated phase transformation (SMPT) in less than 1 min, does not translate to …

Nano-co-crystals enhance the solubility and dissolution rate of poorly soluble drugs. The
objective of this study was to obtain a better understanding of the dissolution process of …

Purpose Solubility and dissolution rate are essential for the oral absorption and
bioavailability of poorly soluble drugs. The aim of this study was to prepare nano-co-crystals …

The increasing number of poorly water-soluble drug candidates in pharmaceutical
development is a major challenge. Enabling techniques such as amorphization of the …