Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …

In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for
faithful chromosome segregation and genome integrity maintenance through cell divisions …

Histone chaperones are key regulators of chromatin structure and function. Their frequent
mis-regulation in various cancers can impact tumor initiation and progression. Here, we …

Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney.
New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The …

Restoring damaged myocardial tissue with therapeutic exogenous cells still has some
limitations, such as immunological rejection, immature cardiac properties, risk of …

Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

The centromeric histone H3 variant CENP-A is overexpressed in many cancers. The
mislocalization of CENP-A to noncentromeric regions contributes to chromosomal instability …

Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …

Abstract Histones H2A, H2B, H3, H4 and H1 are highly conserved, positively charged
proteins which form a disc-shaped protein core around which genomic DNA is wrapped to …

The centromere is a specialized chromosomal structure essential for chromosome
segregation. Centromere dysfunction leads to chromosome segregation errors and genome …