Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …

Electric-acoustic stimulation (EAS) was developed for individuals with a profound hearing
loss in the high frequencies and a substantial residual low-frequency hearing (LFH). For this …

Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to
loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of …

Dizziness and hearing loss are among the most common disabilities. Many forms of
hereditary balance and hearing disorders are caused by abnormal development of …

Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical
impulses that subserve audition,. Loss of hair cells and their innervating neurons is the most …

Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle
requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non …

Inner ear hair cells detect environmental signals associated with hearing, balance, and body
orientation. In humans and other mammals, significant hair cell loss leads to irreversible …

We developed a transgenic mouse to permit conditional and selective ablation of hair cells
in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into …

Sensory epithelia of the inner ear contain two major cell types: hair cells and supporting
cells. It has been clear for a long time that hair cells play critical roles in mechanoreception …

Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …