Highlights•Auditory hair cells play a pivotal role in transducing mechanical energy into
electrical signal.•Mammals have lost their capacity to self-repair damaged cochlear hair cells …

The vestibular system is a critical part of the human balance system, malfunction of this
system will lead to balance disorders, such as vertigo. Mammalian vestibular hair cells, the …

Over 450 million people worldwide suffer from hearing loss, leading to an estimated
economic burden of∼ $750 billion. The past decade has seen significant advances in the …

Strategies to restore sensorineural hearing loss focus on the replacement of lost hair cells,
the specialized mechanoreceptors in the organ of Corti that convert the mechanical energy …

Notch signaling is active during the development of mosaic epithelial sheets and during their
turnover and regeneration. After the loss of hair cells in the mosaic sheet of the vestibular …

Noise‐induced hearing loss (NIHL) poses a significant burden on not only the economics of
health care but also the quality of life of an individual, as we approach an unprecedented …

Objectives/Hypothesis Determine the optimal design characteristics of an adenoviral (Ad)
vector to deliver atoh1 and induce regeneration of vestibular hair cells. Study Design …

Background: A cochlear implant, the only current treatment for restoring auditory perception
after severe or profound sensorineural hearing loss (SNHL), works by electrically stimulating …

Loss of auditory and vestibular hair cells is a common cause of hearing loss and balance
disorders. A variety of strategies have been proposed to restore function to damaged inner …

Bilateral vestibular dysfunction (BVD) refers to hypofunction of the vestibular nerves or
labyrinths on both sides. Patients with BVD present with dizziness, oscillopsia, and …