Direct cellular reprogramming and inner ear regeneration
Introduction: Sound is integral to communication and connects us to the world through
speech and music. Cochlear hair cells are essential for converting sounds into neural …
speech and music. Cochlear hair cells are essential for converting sounds into neural …
Cochlear gene therapy
LR Lustig, O Akil - Current opinion in neurology, 2012 - journals.lww.com
Cochlear gene therapy : Current Opinion in Neurology Cochlear gene therapy : Current Opinion
in Neurology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts …
in Neurology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts …
[HTML][HTML] Improving control of gene therapy-based Neurotrophin delivery for inner ear applications
M St. Peter, DE Brough, A Lawrence… - … in Bioengineering and …, 2022 - frontiersin.org
Background: Survival and integrity of the spiral ganglion is vital for hearing in background
noise and for optimal functioning of cochlear implants. Numerous studies have …
noise and for optimal functioning of cochlear implants. Numerous studies have …
Therapeutic regulation of gene expression in the inner ear using RNA interference
Y Maeda, AM Sheffield, RJH Smith - Gene Therapy of Cochlear …, 2009 - karger.com
Targeting and downregulating specific genes with antisense and decoy oligonucleotides,
ribozymes or RNA interference (RNAi) offer the theoretical potential of altering a disease …
ribozymes or RNA interference (RNAi) offer the theoretical potential of altering a disease …
Spatial and age-dependent hair cell generation in the postnatal mammalian utricle
Z Gao, MC Kelly, D Yu, H Wu, X Lin, F Chi… - Molecular neurobiology, 2016 - Springer
Loss of vestibular hair cells is a common cause of balance disorders. Current treatment
options for bilateral vestibular dysfunction are limited. During development, atonal homolog …
options for bilateral vestibular dysfunction are limited. During development, atonal homolog …
Recent advances in hair cell regeneration research
MS Collado, JC Burns, Z Hu… - Current opinion in …, 2008 - journals.lww.com
Much has been accomplished since the discovery of postembryonic hair cell production and
hair cell regeneration in nonmammals decades ago. No therapies for hair cell regeneration …
hair cell regeneration in nonmammals decades ago. No therapies for hair cell regeneration …
[HTML][HTML] Atoh1 regulation in the cochlea: more than just transcription
YF Cheng - Journal of Zhejiang University. Science. B, 2019 - ncbi.nlm.nih.gov
More than 80% of all cases of deafness are related to the death or degeneration of cochlear
hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these …
hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these …
An in vitro model system to study gene therapy in the human inner ear
BW Kesser, GT Hashisaki, K Fletcher, H Eppard… - Gene therapy, 2007 - nature.com
The confined fluid-filled labyrinth of the human inner ear presents an opportunity for
introduction of gene therapy reagents designed to treat hearing and balance dysfunction …
introduction of gene therapy reagents designed to treat hearing and balance dysfunction …
[HTML][HTML] MYC Gene Delivery to Adult Mouse Utricles Stimulates Proliferation of Postmitotic Supporting Cells In Vitro
JC Burns, JJ Yoo, A Atala, JD Jackson - PLoS One, 2012 - journals.plos.org
The inner ears of adult humans and other mammals possess a limited capacity for
regenerating sensory hair cells, which can lead to permanent auditory and vestibular …
regenerating sensory hair cells, which can lead to permanent auditory and vestibular …
Adeno-associated virus-mediated gene transfer targeting normal and traumatized mouse utricle
Balance dysfunction is closely associated with loss of vestibular hair cells (HCs). Gene
therapy shows promise when used to protect or regenerate vestibular HCs to preserve or …
therapy shows promise when used to protect or regenerate vestibular HCs to preserve or …