Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Incapacitated immune system is a characteristic hallmark of solid tumors. Immune system
within a tumor undergoes an imbalance in cellular dispersion and functionality. Effector cells …

Chimeric antigen receptor T-cells (CAR-Ts) are known as revolutionary living drugs that
have turned the tables of conventional cancer treatments in certain hematologic …

Most studies on genetic engineering technologies for cancer immunotherapy based on
allogeneic donors have focused on adaptive immunity. However, the main limitation of such …

Background Oncolytic viruses reduce tumor burden in animal models and have generated
promising results in clinical trials. However, it is likely that oncolytic viruses will be more …

Adoptively transferred natural killer T (NKT) cells confer distinct cancer surveillance without
causing obvious side effects, making them a promising candidate for cancer …

Reciprocal signaling between immune cells and ovarian cancer cells in the tumor
microenvironment can alter immune responses and regulate disease progression. These …

Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of
tumors. Most mechanistic studies focus on their static functional status before or after …

Purpose Invariant NKT cells (iNKT) are CD1d-restricted T cells with the capacity of antitumor
immunity. The safety of autologous iNKT cell treatment in hepatocellular carcinoma (HCC) …

Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population
that recognize lipid antigens presented by the cluster of differentiation (CD) 1d molecule …