Novel fluid biomarkers for mild cognitive impairment: a systematic review and meta-analysis
A Gaur, L Rivet, E Mah, KK Bawa, D Gallagher… - Ageing Research …, 2023 - Elsevier
Mild cognitive impairment (MCI) is a well-established prodromal stage of dementia (eg,
Alzheimer's disease) that is often accompanied by early signs of neurodegeneration. To …
Alzheimer's disease) that is often accompanied by early signs of neurodegeneration. To …
[HTML][HTML] Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
E Kim, H Kim, MP Jedrychowski, G Bakiasi, J Park… - Neuron, 2023 - cell.com
A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer's disease
A Abdullahi, TWL Wong, SSM Ng - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a very disabling disease. Pathologically, it is characterized by
the presence of amyloid plaques and neurofibrillary tangles in the brain that results in …
the presence of amyloid plaques and neurofibrillary tangles in the brain that results in …
The anti-Alzheimer potential of novel spiroindolin-1, 2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents
H Pourtaher, A Hasaninejad, S Zare, N Tanideh… - Scientific Reports, 2023 - nature.com
In this study, a new series of spiro indolin-1, 2-diazepine were designed, synthesized, and
screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach …
screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach …
Underlying mechanisms of brain aging and neurodegenerative diseases as potential targets for preventive or therapeutic strategies using phytochemicals
HM Abdolmaleky, JR Zhou - Nutrients, 2023 - mdpi.com
During aging, several tissues and biological systems undergo a progressive decline in
function, leading to age-associated diseases such as neurodegenerative, inflammatory …
function, leading to age-associated diseases such as neurodegenerative, inflammatory …
MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons
B Sharma, MM Torres, S Rodriguez… - Neural Regeneration …, 2024 - journals.lww.com
Gamma-aminobutyric acid (GABA) ergic neurons, the most abundant inhibitory neurons in
the human brain, have been found to be reduced in many neurological disorders, including …
the human brain, have been found to be reduced in many neurological disorders, including …
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
RK Godfrey, E Alsop, RT Bjork, BS Chauhan… - Acta neuropathologica …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comprise a spectrum
of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is …
of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is …
Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease
SC Gammie, A Messing, MA Hill, CA Kelm-Nelson… - Plos one, 2024 - journals.plos.org
Alzheimer's disease (AD) is a complex neurodegenerative disorder with both genetic and
non-genetic causes. Animal research models are available for a multitude of diseases and …
non-genetic causes. Animal research models are available for a multitude of diseases and …
Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function
NR Kerr, TJ Kelty, X Mao, TE Childs… - Frontiers in Aging …, 2023 - frontiersin.org
Physical inactivity is the 4th leading cause of death globally and has been shown to
significantly increase the risk for developing Alzheimer's Disease (AD). Recent work has …
significantly increase the risk for developing Alzheimer's Disease (AD). Recent work has …
Transcriptomic Analyses of Exercise Training in Alzheimer's Disease Cerebral Cortex
MA Widjaya, YJ Cheng, YM Kuo, CH Liu… - Journal of …, 2023 - content.iospress.com
Background: Research reported exercise could reduce Alzheimer's disease (AD) symptoms
in human and animals. However, the molecular mechanism of exercise training via …
in human and animals. However, the molecular mechanism of exercise training via …