The Ehlers–Danlos syndromes comprise a clinically and genetically heterogeneous group
of heritable connective tissue disorders, which are characterized by joint hypermobility, skin …

Cellular glycome assembly requires the coordinated action of a large number of
glycosyltransferases that catalyse the transfer of a sugar residue from a donor to specific …

Proteoglycans are important components of cell plasma membranes and extracellular
matrices of connective tissues. They consist of glycosaminoglycan chains attached to a core …

A number of genetic disorders are caused by mutations in the genes encoding
glycosyltransferases and sulfotransferases, enzymes responsible for the synthesis of …

Proteoglycan (PG) synthesis begins with the sequential addition of a “linker chain”, made up
of four sugar residues, to a specific region of a core protein. Defects in the enzymes …

Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …

Proteoglycans consist of a core protein substituted with one or more glycosaminoglycan
(GAG) chains and execute versatile functions during many physiological and pathological …

Proteoglycans are components of the extracellular matrix with diverse biological functions.
Defects in proteoglycan synthesis have been linked to several human diseases with …

Abstract β4GalT7 is a transmembrane Golgi enzyme, encoded by B4GALT7, that plays a
pivotal role in the proteoglycan linker region formation during proteoglycan biosynthesis …

Mutations in B3GALT6, encoding the galactosyltransferase II (GalT-II) involved in the
synthesis of the glycosaminoglycan (GAG) linkage region of proteoglycans (PGs), have …