The demand for glucose uptake and the accompanying enhanced glycolytic energy
metabolism is one of the most important features of cancer cells. Unlike the aerobic …

In recent years, the significant impact of lactate in the tumor microenvironment has been
greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is …

Background B-raf inhibitors (BRAFi) are effective for BRAF-mutated papillary (PTC) and
anaplastic (ATC) thyroid carcinomas, although acquired resistance impairs tumour cells' …

Glycolysis is highly enhanced in pancreatic ductal adenocarcinoma (PDAC) cells; thus,
glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment …

Background Metabolic reprogramming and epigenetic alterations contribute to the
aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone …

Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Simple Summary Cancer remains a major killer of the human population. Current cancer
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …

Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with insidious onset
and early distal metastasis. Metabolic reprogramming, the autonomous changes in cellular …

Malignant Pleural Mesothelioma (MPM) is a rare neoplasm that is typically diagnosed in a
locally advanced stage, making it not eligible for radical surgery and requiring systemic …

Cisplatin (CPT) is one of the standard treatments for hepatocellular carcinoma (HCC).
However, its use is limits as a monotherapy due to drug resistance, and the underlying …