The overexpression of σ receptors (σRs) in various types of tumors has prompted a deep
investigation of their role in cancer pathophysiology. Consequently, σR ligands have been …

Pro-inflammatory cytokine production by the retinal pigment epithelium (RPE) is a key
etiology in retinal degenerative diseases, yet the underlying mechanisms are not well …

Prion diseases are invariably fatal neurodegenerative diseases of humans and other
animals for which there are no effective treatment options. Previous work from our laboratory …

Previous studies have shown that ligands that bind to sigma-2 receptor/TMEM97
(s2R/TMEM97), a transmembrane protein, have anxiolytic/antidepressant-like properties …

Ukrainian companies occupy an important niche in the global drug discovery process;
however, before the Russian invasion, the role of Ukraine was not obvious. The biggest …

A new sigma-2 (σ2) receptor ligand (FA4) was efficiently synthesized and evaluated for
cytotoxic, proapoptotic, and antimigratory activity on pancreatic ductal adenocarcinoma …

The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R)
comprise a unique class of drug binding sites. Their alleles are associated with human …

Neuropathic pain (NP) is a prevalent medical condition that lacks an effective treatment.
Recently, the Sigma-2 receptor (S2R) has been proposed as a potential therapeutic target …

Amines and carboxylic acids are abundant chemical feedstocks that are nearly exclusively
united via the amide coupling reaction. The disproportionate use of the amide coupling …

The COVID-19 caused by SARS-CoV-2 has led to a global pandemic that continues to
impact societies and economies worldwide. The main protease (M pro) plays a crucial role …