The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

RJ Henry, RM Ritzel, JP Barrett, SJ Doran… - Journal of …, 2020 - Soc Neuroscience
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

Neurofilament light as a biomarker in traumatic brain injury

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether serum neurofilament light (NfL) correlates with CSF NfL,
traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor …

Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation

DJ Loane, A Kumar, BA Stoica… - … of Neuropathology & …, 2014 - academic.oup.com
Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is …

A decade of DTI in traumatic brain injury: 10 years and 100 articles later

MB Hulkower, DB Poliak… - American Journal …, 2013 - Am Soc Neuroradiology
The past decade has seen an increase in the number of articles reporting the use of DTI to
detect brain abnormalities in patients with traumatic brain injury. DTI is well-suited to the …

Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury

AI Faden, J Wu, BA Stoica… - British journal of …, 2016 - Wiley Online Library
Traumatic brain injury (TBI) has been linked to dementia and chronic neurodegeneration.
Described initially in boxers and currently recognized across high contact sports, the …

[HTML][HTML] Diffusion tensor imaging of cerebral white matter integrity in cognitive aging

DJ Madden, IJ Bennett, A Burzynska, GG Potter… - … et Biophysica Acta (BBA …, 2012 - Elsevier
In this article we review recent research on diffusion tensor imaging (DTI) of white matter
(WM) integrity and the implications for age-related differences in cognition. Neurobiological …

Diffuse axonal injury predicts neurodegeneration after moderate–severe traumatic brain injury

NSN Graham, A Jolly, K Zimmerman, NJ Bourke… - Brain, 2020 - academic.oup.com
Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such
as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models …

Subconcussive head impact exposure and white matter tract changes over a single season of youth football

N Bahrami, D Sharma, S Rosenthal, EM Davenport… - Radiology, 2016 - pubs.rsna.org
Purpose To examine the effects of subconcussive impacts resulting from a single season of
youth (age range, 8–13 years) football on changes in specific white matter (WM) tracts as …