The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Protein–RNA complexes exist in many forms within the cell, from stable machines such as
the ribosome to transient assemblies like the spliceosome. All protein–RNA assemblies rely …

Abstract N4-acetylcytidine (ac4C) is a vital constituent of the epitranscriptome and plays a
crucial role in the regulation of mRNA expression. Numerous studies have established …

Transcriptomics methods (RNA-Seq, PCR) today are more routine and reproducible than
proteomics methods, ie, both mass spectrometry and immunochemical analysis. For this …

Synthesis of DNA fragments based on gene sequences that are available in public
resources has become an efficient and affordable method that has gradually replaced …

2′-O-methylation (2-OM or Nm) is a widespread RNA modification observed in various
RNA types like tRNA, mRNA, rRNA, miRNA, piRNA, and snRNA, which plays a crucial role …

Elucidating the intricate interactions between viral pathogens and host cellular machinery
during infection is paramount for understanding pathogenic mechanisms and identifying …

Abstract N 6-methyladenosine (m6A) has been established as the most prevalent chemical
modification in message RNA (mRNA), playing an essential role in determining the fate of …

The N6-methyladenosine modification is one of the most abundant post-transcriptional
modifications in ribonucleic acid (RNA) molecules. Using molecular dynamics simulations …

In Trypanosoma brucei, gene expression is primarily regulated posttranscriptionally making
RNA metabolism critical. T. brucei has an epitranscriptome containing modified RNA bases …