Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

Clathrin-mediated endocytosis in the budding yeast Saccharomyces cerevisiae involves the
ordered recruitment, activity and disassembly of nearly 60 proteins at distinct sites on the …

Several determinants of aging, including metabolic capacity and genetic stability, are
recognized in both yeast and humans. However, many aspects of the pathways leading to …

Interactions between mitochondria and the cytoskeleton are essential for normal
mitochondrial morphology, motility and distribution. While microtubules and their motors …

SH3 domains are peptide recognition modules that mediate the assembly of diverse
biological complexes. We scanned billions of phage-displayed peptides to map the binding …

Understanding how numerous actin-binding proteins (ABPs) work in concert to control the
assembly, organization, and turnover of the actin cytoskeleton requires quantitative …

Early endosomes, also called sorting endosomes, are known to mature into late endosomes
via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence …

The actin cytoskeleton is a complex network of dynamic polymers, which plays an important
role in various fundamental cellular processes, including maintenance of cell shape …