Neuroactive compounds are synthesized by certain plants and microorganisms by
undertaking different tasks, especially as a stress response. Most common neuroactive …

A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …

Objective Psychobiotics, as a novel class of probiotics mainly acting on the gut-brain axis,
have shown promising prospects in treating psychiatric disorders. Bifidobacterium breve …

Background Accumulating evidence points to an association between gut microbial
abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

Depression disorder is rapidly advancing worldwide, and therapeutic strategy through gut–
brain axis has been proven to be effective in the treatment. Here we studied the effect of …

Depression is a debilitating mental disorder that affects> 322 million people worldwide.
Despite the availability of several antidepressant agents, many patients remain treatment …

Background & Aims Mood disorders and constipation are often comorbid, yet their shared
etiologies have rarely been explored. The neurotransmitter serotonin (5-HT) regulates …

Background Relevant studies have shown that gut microbiome plays an important role in the
occurrence, development and treatment of major depressive disorder (MDD). Many studies …

To explore mechanism of intestinal flora dysregulation promoting constipation, 60 specific
pathogen-free (SPF) mice were used as research objects and were treated with constipation …