Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling
has enriched our understanding of cancer initiation and progression and has become …

Cancer chemoprevention approaches are aimed at preventing, delaying, or suppressing
tumor incidence using synthetic or natural bioactive agents. Mechanistically …

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Circulating tumor DNA (ctDNA) provides a noninvasive approach to elucidate a patient's
genomic landscape and actionable information. Here, we design a ctDNA-based study of …

The history of lung cancer epidemiology parallels the history of modern chronic disease
epidemiology. Although an excess of lung cancer was firstly observed among miners and …

Lung carcinogenesis is a complex and stepwise process involving accumulation of genetic
mutations in signaling and oncogenic pathways via interactions with environmental factors …

The epidermal growth factor receptor (EGFR) pathway is a well-studied oncogenic pathway
in human non-small cell lung cancer (NSCLC). A subset of advanced NSCLC patients (15 …

Targeted therapy of treating patients with specific tyrosine kinase inhibitors (TKIs) is currently
the standard care for epidermal growth factor receptor (EGFR) mutant non-small cell lung …

Lung cancer is the second most common cancer and the leading cause of cancer-related
death worldwide. Molecular imaging using [18 F] fluorodeoxyglucose Positron Emission …

Immune checkpoint blockade with PD-(L) 1 antibodies has revolutionized the treatment of
advanced non-small cell lung cancer (NSCLC). Similarly, the identification and targeting of …