Abstract Development of nervous tissue is controlled, in part, by the ornithine decarboxylase
(ODC)/polyamine system. Each brain region possesses a unique ontogenetic pattern for …

Using data derived from clinical and experimental observations, we examine the role of the
myocardial β-adrenergic receptor system in pathophysiologic processes involved in heart …

Skeletal muscle atrophy is a common and debilitating condition that remains poorly
understood at the molecular level. To better understand the mechanisms of muscle atrophy …

The polyamines putrescine, spermidine and spermine are natural components of all living
cells. Although their exact cellular functions are still largely unknown, a constant supply of …

The role of thyroid hormone in the control of cardiac and renal cell development was
examined in neonatal rats made hyperthyroid by administration of triiodothyronine (T3, 0.1 …

Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B).
We determined whether UT-A proteins could be detected in heart and whether their …

The aliphatic amines putrescine, spermidine and spermine are natural polycations widely
distributed in prokariotic and eukariotic ceils. Although they have been known for over 300 …

Ornithine decarboxylase (ODC) and the polyamines are thought to play a role in maturation
of mammalian tissues. Daily postnatal administration of α‐difluoromethylornithine (DFMO, a …

Abstract α-Difluoromethylornithine specifically and irreversibly inhibits the enzyme ornithine
decarboxylase. Ornithine decarboxylase catalyses the initial step in the synthesis of …

This study tested the hypothesis that the polyamines, a family of low-molecular-weight
organic cations with documented regulatory roles in cell growth and differentiation, are …