Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB)
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …

Immune checkpoints consist of inhibitory and stimulatory pathways that maintain self-
tolerance and assist with immune response. In cancer, immune checkpoint pathways are …

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …

Background Understanding the interactions between tumor and the host immune system is
critical to finding prognostic biomarkers, reducing drug resistance, and developing new …

Conspectus Nanomedicine holds significant potential to improve the efficacy of cancer
immunotherapy. Thus far, nanomedicines, ie, 1–100 (0) nm sized drug delivery systems …

Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of
only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the …

Abstract Purpose: Combination PD-1 and CTLA-4 inhibitor therapy has dramatically
improved the survival of patients with advanced melanoma but is also associated with …

Combination therapy that could better balance immune activation and suppressive signals
holds great potential in cancer immunotherapy. Herein, we serendipitously found that the pH …

Until now, three types of well‐recognized cancer treatments have been developed, ie,
surgery, chemotherapy, and radiotherapy; these either remove or directly attack the cancer …

Melanin is capable of transforming 99.9% of the absorbed sunlight energy into heat,
reducing the risk of skin cancer. We here develop a melanin-mediated cancer …