Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Simple Summary Glucose is the main fuel cell used for energy production via a series of
enzymatic reactions in the presence of oxygen in a process known as aerobic respiration …

Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Parthenolide (PTL) is a sesquiterpene lactone derived from medicinal plant feverfew
(Tanacetum parthenium). Recent studies have demonstrated that it has multiple …

Simple Summary In the complex world of cancer, iron and copper play essential roles as
trace metal ions that are crucial for cancer cell survival. Disruption in their metabolic …

Cancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor
growth and cause recurrence and metastasis. CSCs are particularly resistant to …

Simple Summary Mitochondria are organelles involved in different biological processes,
including tumorigenesis. Accumulating evidence strongly supports that, despite the …

Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment
recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence …

Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older
patients, and the identification of potential therapeutic targets for AML is problematic …

Despite enormous efforts being invested in the development of novel therapies for brain
malignancies, there remains a dire need for effective treatments, particularly for pediatric …