The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of
mortality and age-related diseases in men, but the causal and mechanistic relationships …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Abstract The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

Endocrine, nervous, and immune systems work coordinately to maintain the global
homeostasis of the organism. They show sex differences in their functions that, in turn …

Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …

Mosaic loss of Chromosome Y (LOY) is a common acquired structural mutation in the
leukocytes of aging men that is correlated with several age-related diseases, including …

Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated
with increased risk for morbidity and mortality. The CD99 gene, positioned in the …

Neurological conditions such as Alzheimer's disease (AD) and related dementias (ADRD)
present with many challenges due to the heterogeneity of the related disease (s), making it …

Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier
onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro …