[HTML][HTML] An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT …
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …
cells need a mammoth supply of glucose for which they display an upregulated expression …
Effects of Polyphenols on Glucose‐Induced Metabolic Changes in Healthy Human Subjects and on Glucose Transporters
G Williamson - Molecular Nutrition & Food Research, 2022 - Wiley Online Library
Dietary polyphenols interact with glucose transporters in the small intestine and modulate
glucose uptake after food or beverage consumption. This review assesses the transporter …
glucose uptake after food or beverage consumption. This review assesses the transporter …
[HTML][HTML] Kidney proximal tubule GLUT2—more than meets the eye
M Ahmad, I Abramovich, B Agranovich, A Nemirovski… - Cells, 2022 - mdpi.com
Tubulopathy plays a central role in the pathophysiology of diabetic kidney disease (DKD).
Under diabetic conditions, the kidney proximal tubule cells (KPTCs) are exposed to an …
Under diabetic conditions, the kidney proximal tubule cells (KPTCs) are exposed to an …
Discrimination of GLUTs by Fructose Isomers Enables Simultaneous Screening of GLUT5 and GLUT2 Activity in Live Cells
N Gora, LJ Weselinski, VV Begoyan… - ACS chemical …, 2023 - ACS Publications
Facilitative carbohydrate transporters (GLUTs, SLC2 gene family) are transmembrane
proteins transporting hexoses and other sugars based on cellular metabolic demands. While …
proteins transporting hexoses and other sugars based on cellular metabolic demands. While …
[HTML][HTML] GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems
The passive transport of glucose and related hexoses in human cells is facilitated by
members of the glucose transporter family (GLUT, SLC2 gene family). GLUT3 is a high …
members of the glucose transporter family (GLUT, SLC2 gene family). GLUT3 is a high …
[HTML][HTML] Glutor, a glucose transporter inhibitor, exerts antineoplastic action on tumor cells of thymic origin: Implication of modulated metabolism, survival, oxidative …
Neoplastic cells overexpress glucose transporters (GLUT), particularly GLUT1 and GLUT3,
to support altered metabolism. Hence, novel strategies are being explored to inhibit GLUTs …
to support altered metabolism. Hence, novel strategies are being explored to inhibit GLUTs …
Virtual screening and in vitro validation of natural compound inhibitors against SARS-CoV-2 spike protein
The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to a major public health
burden and has resulted in millions of deaths worldwide. As effective treatments are limited …
burden and has resulted in millions of deaths worldwide. As effective treatments are limited …
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect
Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation
even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate …
even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate …
[HTML][HTML] Dietary polyphenols and in vitro intestinal fructose uptake and transport: a systematic literature review
S Iametti, F Bonomi, M Di Nunzio - International Journal of Molecular …, 2022 - mdpi.com
Recent evidence links chronic consumption of large amounts of fructose (FRU) with several
non-communicable disease. After ingestion, dietary FRU is absorbed into the intestinal tract …
non-communicable disease. After ingestion, dietary FRU is absorbed into the intestinal tract …
[HTML][HTML] Fenofibrate reduces glucose-induced barrier dysfunction in feline enteroids
CK Crawford, A Beltran, D Castillo, MS Matloob… - Scientific Reports, 2023 - nature.com
Diabetes mellitus (DM) is a common chronic metabolic disease in humans and household
cats that is characterized by persistent hyperglycemia. DM is associated with dysfunction of …
cats that is characterized by persistent hyperglycemia. DM is associated with dysfunction of …