Abnormalities in the process of uterine muscle contractility during pregnancy and birth can
have major clinical implications, including preterm labour, which is the single largest cause …

ROCK (Rho-kinase), an effector molecule of RhoA, phosphorylates the myosin binding
subunit (MBS) of myosin phosphatase and inhibits the phosphatase activity. This inhibition …

The microtubule-organizing center (MTOC) is reoriented between the nucleus and the
leading edge in many migrating cells and contributes to directional migration. Models …

We examined the role of regulatory myosin light chain (MLC) phosphorylation of myosin II in
cell migration of fibroblasts. Myosin light chain kinase (MLCK) inhibition blocked MLC …

Lymphocyte traffic is required to maintain homeostasis and perform appropriate
immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial …

AMP-activated protein kinase (AMPK, also known as SNF1A) has been primarily studied as
a metabolic regulator that is activated in response to energy deprivation. Although there is …

Progestin withdrawal is a crucial event for the onset of labor in many mammalian species.
However, in humans the mechanism of a functional progestin withdrawal is unclear …

The scattering of Madin-Darby canine kidney cells in vitro mimics key aspects of epithelial–
mesenchymal transitions during development, carcinoma cell invasion, and metastasis …

Objective: We recently demonstrated in our swine model of coronary artery spasm that
enhanced myosin light chain (MLC) phosphorylations (both MLC mono-and …

Integrin engagement generates cellular signals leading to the recruitment of structural and
signalling molecules which, in concert with rearrangements of the actin cytoskeleton, leads …