Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) has been
tested in advanced melanoma patients at various centers. We conducted a systematic …

Simple Summary Despite remarkable progress being made by preventive medical check-
ups in the last decades, colorectal cancer (CRC) remains one of the most frequent and …

Recent clinical evidence has demonstrated that microsatellite instability (MSI) or defective
mismatch repair (MMR) and high tumor mutational load can predict response to the …

Background In the past decade, systematic and comprehensive analyses of cancer
genomes have identified cancer driver genes and revealed unprecedented insight into the …

Simple Summary Microsatellite instability (MSI) has been detected in multiple types of
gynecologic cancers. MSI is linked to mutations in mismatch repair (MMR) genes that cause …

Somatic mutations binding to the patient's MHC and recognized by autologous T cells
(neoepitopes) are ideal cancer vaccine targets. They combine a favorable safety profile due …

Context.—Cancer immunotherapy provides unprecedented rates of durable clinical benefit
to late-stage cancer patients across many tumor types, but there remains a critical need for …

Introduction: In the last few years, significant advances in molecular biology have provided
new therapeutic options for colorectal cancer (CRC). The development of new drugs that …

Deficient DNA mismatch repair causes a robust mutator phenotype known as microsatellite
instability (MSI). MSI is a feature of Lynch syndrome-related cancers and is also found in …

Objectives: Sessile serrated polyps (SSPs) are suggested to be the precursors of 15–30% of
all colorectal cancers (CRCs). Therefore, CRC screening modalities should also be …