Harnessing cancer stem cell-derived exosomes to improve cancer therapy
J Yang, Y Teng - Journal of Experimental & Clinical Cancer Research, 2023 - Springer
Cancer stem cells (CSCs) are the key “seeds” for tumor initiation and development,
metastasis, and recurrence. Because of the function of CSCs in tumor development and …
metastasis, and recurrence. Because of the function of CSCs in tumor development and …
Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer
S Liang, J Hess - Cells, 2024 - mdpi.com
The neurobiology of tumors has attracted considerable interest from clinicians and scientists
and has become a multidisciplinary area of research. Neural components not only interact …
and has become a multidisciplinary area of research. Neural components not only interact …
Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ
W Luo, Y Jin, Y Jiang, L Yang, H Xu, D Wu… - Cell Death & …, 2023 - nature.com
Abstract Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is
involved in neurogenesis, and its levels are elevated in various human cancers. Recent …
involved in neurogenesis, and its levels are elevated in various human cancers. Recent …
HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway
H Ma, G Qi, F Han, P Gai, J Peng, B Kong - Cell Communication and …, 2023 - Springer
Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading
cause of cancer-related mortality among women. Our previous study revealed that high …
cause of cancer-related mortality among women. Our previous study revealed that high …
RBM15 m6A modification‐mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling
Y Song, Q Wu - Environmental toxicology, 2023 - Wiley Online Library
Cervical cancer (CC) is a deadly gynecological tumor worldwide. Otubain 2 (OTUB2) has
been recently identified as an oncogene in human malignancies. However, its expression …
been recently identified as an oncogene in human malignancies. However, its expression …
From Inflammation to Oncogenesis: Tracing Serum DCLK1 and miRNA Signatures in Chronic Liver Diseases
LL Moore, D Qu, S Sureban, S Mitchell, K Pitts… - International Journal of …, 2024 - mdpi.com
Chronic liver diseases, fibrosis, cirrhosis, and HCC are often a consequence of persistent
inflammation. However, the transition mechanisms from a normal liver to fibrosis, then …
inflammation. However, the transition mechanisms from a normal liver to fibrosis, then …
Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells
LL Moore, CW Houchen - International Journal of Molecular Sciences, 2023 - mdpi.com
While significant strides have been made in understanding cancer biology, the
enhancement in patient survival is limited, underscoring the urgency for innovative …
enhancement in patient survival is limited, underscoring the urgency for innovative …
Doublecortin-like kinase is required for cnidocyte development in Nematostella vectensis
JEM Kraus, H Busengdal, Y Kraus, H Hausen… - Neural …, 2024 - Springer
The complex morphology of neurons requires precise control of their microtubule
cytoskeleton. This is achieved by microtubule-associated proteins (MAPs) that regulate the …
cytoskeleton. This is achieved by microtubule-associated proteins (MAPs) that regulate the …
Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation
P Pan, D Ji, Z Li, X Meng - Journal of Enzyme Inhibition and …, 2024 - Taylor & Francis
Abstract Doublecortin-like kinase 1 (DCLK) is a microtubule-associated serine/threonine
kinase that is upregulated in a wide range of cancers and is believed to be related to tumour …
kinase that is upregulated in a wide range of cancers and is believed to be related to tumour …
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome
XY Chen, C Kao, SW Peng, JH Chang, YL Lee… - Molecular …, 2023 - Springer
Background Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to
higher mortality in patients with acute respiratory distress syndrome (ARDS). However, the …
higher mortality in patients with acute respiratory distress syndrome (ARDS). However, the …