Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Depression is a multicausal disorder and has been associated with the risk to develop
cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Bipolar disorder, one of the most distinct syndromes in psychiatry, has been described in
numerous cultures throughout history. The unique hallmark of the illness is mania, which is …

Oxidative stress has been implicated in the pathophysiology of many neuropsychiatric
disorders such as schizophrenia, bipolar disorder, major depression etc. Both genetic and …

Bipolar, or manic-depressive, disorder is a frequent, severe, mostly recurrent mood disorder
associated with great morbidity. The lifetime prevalence of bipolar disorder is 1· 3 to 1· 6 …

Inositols are sugar-like compounds that are widely distributed in nature and are a part of
membrane molecules, participating as second messengers in several cell-signaling …

Mood disorders are a major public health problem and are associated with considerable
burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of …

OBJECTIVE: Clinicians have few evidence-based options for the management of treatment-
resistant bipolar depression. This study represents the first randomized trial of competing …

In this paper, we propose that lithium may exert its therapeutic effect in bipolar disorder by
acting on insulin signaling pathways. Specifically, we assess the importance of the …