Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors

H Singh, DK Agrawal - Drug development research, 2022 - Wiley Online Library
Receptor for advanced glycation end products (RAGE) is a 45 kDa transmembrane receptor
of immunoglobulin family that can bind to various endogenous and exogenous ligands and …

S100 proteins in fatty liver disease and hepatocellular carcinoma

E Delangre, E Oppliger, S Berkcan… - International journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent and slow progressing hepatic
pathology characterized by different stages of increasing severity which can ultimately give …

Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression

D Gou, R Liu, X Shan, H Deng, C Chen… - The Journal of …, 2023 - Am Soc Clin Investig
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a
promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic …

Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4

Q Meng, C Chen, N Yang… - Proceedings of the …, 2023 - National Acad Sciences
Senescent cells are beneficial for repairing acute tissue damage, but they are harmful when
they accumulate in tissues, as occurs with advancing age. Senescence-associated …

Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats

RT McCallum, RK Thériault, JD Manduca… - Biology of sex …, 2024 - Springer
Background Major depressive disorder (MDD) is a recurring affective disorder that is two
times more prevalent in females than males. Evidence supports immune system dysfunction …

S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry

TO Mohammed, YR Lin, L Akter… - Journal of Cell …, 2024 - journals.biologists.com
ABSTRACT S100A11 is a small Ca2+-activatable protein known to localize along stress
fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed …

Serum proteomics identifies S100A11 and MMP9 as novel biomarkers for predicting the early efficacy of sublingual immunotherapy in allergic rhinitis

Y Zhang, J Shui, L Wang, F Wang - International Immunopharmacology, 2023 - Elsevier
Background Allergic rhinitis (AR) is a chronic inflammatory disorder, and sublingual
immunotherapy (SLIT) is an important therapy. However, SLIT exhibits a wide range of …

Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs

C Deng, Y Xu, H Chen, X Zhu, L Huang, Z Chen, H Xu… - Cell Reports, 2024 - cell.com
The premetastatic niche (PMN) contributes to lung-specific metastatic tropism in
osteosarcoma. However, the crosstalk between primary tumor cells and lung stromal cells is …

S-100 proteins: basics and applications as biomarkers in animals with special focus on calgranulins (S100A8, A9, and A12)

JJ Cerón, A Ortín-Bustillo, MJ López-Martínez… - Biology, 2023 - mdpi.com
Simple Summary S100 proteins are a group of calcium-binding proteins which have a
similar molecular mass and share similarities in their amino acid sequence. They are …

S100A11 activates the pentose phosphate pathway to induce malignant biological behaviour of pancreatic ductal adenocarcinoma

X Zeng, H Guo, Z Liu, Z Qin, Y Cong, N Ren… - Cell Death & …, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory malignancies and
has a poor prognosis. In recent years, increasing evidence has shown that an imbalance of …