Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors
H Singh, DK Agrawal - Drug development research, 2022 - Wiley Online Library
Receptor for advanced glycation end products (RAGE) is a 45 kDa transmembrane receptor
of immunoglobulin family that can bind to various endogenous and exogenous ligands and …
of immunoglobulin family that can bind to various endogenous and exogenous ligands and …
S100 proteins in fatty liver disease and hepatocellular carcinoma
E Delangre, E Oppliger, S Berkcan… - International journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent and slow progressing hepatic
pathology characterized by different stages of increasing severity which can ultimately give …
pathology characterized by different stages of increasing severity which can ultimately give …
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression
D Gou, R Liu, X Shan, H Deng, C Chen… - The Journal of …, 2023 - Am Soc Clin Investig
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a
promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic …
promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic …
Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
Senescent cells are beneficial for repairing acute tissue damage, but they are harmful when
they accumulate in tissues, as occurs with advancing age. Senescence-associated …
they accumulate in tissues, as occurs with advancing age. Senescence-associated …
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats
RT McCallum, RK Thériault, JD Manduca… - Biology of sex …, 2024 - Springer
Background Major depressive disorder (MDD) is a recurring affective disorder that is two
times more prevalent in females than males. Evidence supports immune system dysfunction …
times more prevalent in females than males. Evidence supports immune system dysfunction …
S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry
TO Mohammed, YR Lin, L Akter… - Journal of Cell …, 2024 - journals.biologists.com
ABSTRACT S100A11 is a small Ca2+-activatable protein known to localize along stress
fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed …
fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed …
Serum proteomics identifies S100A11 and MMP9 as novel biomarkers for predicting the early efficacy of sublingual immunotherapy in allergic rhinitis
Y Zhang, J Shui, L Wang, F Wang - International Immunopharmacology, 2023 - Elsevier
Background Allergic rhinitis (AR) is a chronic inflammatory disorder, and sublingual
immunotherapy (SLIT) is an important therapy. However, SLIT exhibits a wide range of …
immunotherapy (SLIT) is an important therapy. However, SLIT exhibits a wide range of …
Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
C Deng, Y Xu, H Chen, X Zhu, L Huang, Z Chen, H Xu… - Cell Reports, 2024 - cell.com
The premetastatic niche (PMN) contributes to lung-specific metastatic tropism in
osteosarcoma. However, the crosstalk between primary tumor cells and lung stromal cells is …
osteosarcoma. However, the crosstalk between primary tumor cells and lung stromal cells is …
S-100 proteins: basics and applications as biomarkers in animals with special focus on calgranulins (S100A8, A9, and A12)
JJ Cerón, A Ortín-Bustillo, MJ López-Martínez… - Biology, 2023 - mdpi.com
Simple Summary S100 proteins are a group of calcium-binding proteins which have a
similar molecular mass and share similarities in their amino acid sequence. They are …
similar molecular mass and share similarities in their amino acid sequence. They are …
S100A11 activates the pentose phosphate pathway to induce malignant biological behaviour of pancreatic ductal adenocarcinoma
X Zeng, H Guo, Z Liu, Z Qin, Y Cong, N Ren… - Cell Death & …, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory malignancies and
has a poor prognosis. In recent years, increasing evidence has shown that an imbalance of …
has a poor prognosis. In recent years, increasing evidence has shown that an imbalance of …