Advancing cell-based cancer immunotherapy through stem cell engineering

YR Li, ZS Dunn, Y Yu, M Li, P Wang, L Yang - Cell Stem Cell, 2023 - cell.com
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

Natural quinazolinones: From a treasure house to promising anticancer leads

H Li, G Fu, W Zhong - European Journal of Medicinal Chemistry, 2023 - Elsevier
Despite great advances in the development of modern anticancer drugs, it is still challenging
to find safer and more effective ones due to a new spectrum of diseases and emerging drug …

Revolutionizing cancer treatment: comprehensive insights into immunotherapeutic strategies

NR Raghani, MR Chorawala, M Mahadik, RB Patel… - Medical Oncology, 2024 - Springer
Cancer, characterized by the uncontrolled proliferation of aberrant cells, underscores the
imperative for innovative therapeutic approaches. Immunotherapy has emerged as a pivotal …

[HTML][HTML] Immunotherapeutic approaches in Hepatocellular carcinoma: Building blocks of hope in near future

N Minaei, R Ramezankhani, A Tamimi, A Piryaei… - European Journal of …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of primary hepatic cancer and is
among the major causes of mortality due to cancer. Due to the lack of efficient conventional …

Natural killer cells in chronic lymphocytic leukemia: functional impairment and therapeutic potential

M Yano, JC Byrd, N Muthusamy - Cancers, 2022 - mdpi.com
Simple Summary Natural killer (NK) cells are immune cells with potent anti-tumor and anti-
infection activity. The potential benefit of NK cell therapy against chronic lymphocytic …

NK and cells with NK-like activities in cancer immunotherapy-clinical perspectives

K Mortezaee, J Majidpoor - Medical Oncology, 2022 - Springer
Natural killer (NK) cells are lymphoid cells of innate immunity that take important roles in
immune surveillance. NK cells are considered as a bridge between innate and adaptive …

Immunotherapeutic strategies for neuroblastoma: present, past and future

F Morandi, F Sabatini, M Podestà, I Airoldi - Vaccines, 2021 - mdpi.com
Neuroblastoma is the most common extracranial pediatric solid tumor with a heterogeneous
clinical course, ranging from spontaneous regression to metastatic disease and death …

[HTML][HTML] Cellular immunotherapy for hematological malignancy: recent progress and future perspectives

Z Xu, X Huang - Cancer Biology & Medicine, 2021 - ncbi.nlm.nih.gov
Advancements in the field of cellular immunotherapy have accelerated in recent years and
have changed the treatment landscape for a variety of hematologic malignancies. Cellular …

Red blood cell rosetting enables size-based separation of specific lymphocyte subsets from blood in a microfluidic device

K Abhishek, ASCLS Titus, MTP Dinh… - Lab on a Chip, 2023 - pubs.rsc.org
The isolation of a specific lymphocyte subset from blood is the required first step in the
manufacturing of many novel cellular immunotherapies. Microfluidic size-based separation …

[HTML][HTML] KIR2DS2 expression identifies NK cells with enhanced anticancer activity

MD Blunt, A Vallejo Pulido, JG Fisher… - The Journal of …, 2022 - journals.aai.org
NK cells are promising cellular therapeutics against hematological and solid malignancies.
Immunogenetic studies have identified that various activating killer cell Ig-like receptors …