The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Serotonin, also known as 5-hydroxytryptamine (5-HT) is a signaling mediator that regulates
emotion, behavior, and cognition. Previous studies have focused more on the roles of 5-HT …

Appropriate processing of reward and aversive information is essential for survival. Although
a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward …

Anxiety disorders are currently a major psychiatric and social problem, the mechanisms of
which have been only partially elucidated. The hippocampus serves as a major target of …

Anxiety disorders may be mediated in part by disruptions in serotonin (5-hydroxytryptamine,
5-HT) system function. Behavioral measures of approach-avoidance conflict suggest that …

Central post-stroke pain (CPSP) and associated depression remain poorly understood and
pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested …

Major depressive disorder (MDD) and its treatment are challenges for global health.
Optogenetics and chemogenetics are driving MDD research forward by unveiling causal …

Icariin is a prenylated flavonol glycoside isolated from Epimedium herb, and has been
shown to be its main bioactive component. Recently, the antidepressant-like mechanism of …

Ether phospholipid compositions are altered in the plasma or brain of patients with brain
disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric …