Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …

Adenoviruses have been studied intensively for over 50 years as models of virus–cell
interactions and latterly as gene vectors. With the advent of more sophisticated structural …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection,
but its physiologic functions have not been described. In nonpolarized cells, CAR localized …

Adenoviruses have been characterized extensively since their initial description in the early
1950s (Hillemann & Werner, 1954; Rowe et al., 1953) and there is now a panoply of …

In 1996, in a discussion of adenovirus biology in a standard virology textbook, it was noted
that “the identity of the cellular receptor remains a mystery”(78). In the past few years, not just …

Persistence of adenovirus type 5 in blood has implications for the pathogenicity of the virus
infection and for the use of this virus in oncolysis and gene therapy. In this study, the kinetics …

Adenoviruses (Ad) are efficient vehicles for gene delivery in vitro and in vivo. Therefore, they
are a promising tool in gene therapy, particularly in the treatment of cancer and …

Most studies on TCF7L2 SNP variants in the pathogenesis of type 2 diabetes (T2D) focus on
a role of the encoded transcription factor TCF4 in β cells. Here, a mouse genetics approach …

Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …