The development of cancer begins with cells transitioning from their multicellular nature to a
state akin to unicellular organisms. This shift leads to a breakdown in the crucial regulators …

The Y chromosome has recognized functions in promoting male sex determination and
regulating aspects of fertility. However, recent work has demonstrated important roles for the …

Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the phenomenon where a
hematopoietic stem cell acquires fitness-increasing mutation (s), resulting in its clonal …

Simple Summary We were motivated by the need to improve early detection of bladder
cancer (BLCA). Our aim was to uncover genetic alterations within the bladder's lining, called …

Somatic mutations acquired in haematopoietic stem cells can drive clonal expansions, a
phenomenon called clonal haematopoiesis (CH). CH has been associated with higher risk …

Clonal expansion of hematopoietic cells is first observed in hematological malignancies
where all the leukemic cells can be traced back to a single cell carrying oncogenic …

Sex differences are observed in a myriad of diseases and often attributed to differences in
hormones or lifestyle between males and females. However, the puzzle of sex differences …

Cellular therapies have started an important new therapeutic direction for Autistic Spectrum
Disease (ASD), and the ample diversity of ASD pathophysiology and the different types of …

Have you ever wondered how jet-setting across the globe might affect your gut health? A
recent study has dug into this intriguing question, revealing that travel can have some …