The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

Dementia and depression: biological connections with amyloid β protein

HM Dos Santos, AG Bertollo… - Basic & Clinical …, 2024 - Wiley Online Library
Dementia is an umbrella term for a broad group of age‐associated neurodegenerative
diseases. It is estimated that dementia affects 50 million people worldwide and that …

Depression and cognition are associated with lipid dysregulation in both a multigenerational study of depression and the National Health and Nutrition Examination …

SMA Mehdi, AP Costa, C Svob, L Pan… - Translational …, 2024 - nature.com
Chronic dysregulation of peripheral lipids has been found to be associated with depression
and cognition, but their interaction has not been investigated. Growing evidence has …

Indoleamine 2, 3-dioxygenase as a therapeutic target for Alzheimer's disease and geriatric depression

K Savonije, A Meek, DF Weaver - Brain Sciences, 2023 - mdpi.com
Neuroimmune-triggered neuroinflammation of the central nervous system is emerging as an
important aetiopathogenic factor for multiple neurological disorders, including depression …

c-Diadem: a constrained dual-input deep learning model to identify novel biomarkers in Alzheimer's disease

S Jemimah, A AlShehhi… - BMC Medical …, 2023 - Springer
Background Alzheimer's disease (AD) is an incurable, debilitating neurodegenerative
disorder. Current biomarkers for AD diagnosis require expensive neuroimaging or invasive …

The A-to-Z factors associated with cognitive impairment. Results of the DeCo study

M Gil-Peinado, M Alacreu, H Ramos… - Frontiers in …, 2023 - frontiersin.org
Introduction Cognitive impairment (CI) is known to be mediated by several risk and
protective factors, many of which are potentially modifiable. Therefore, it is important to have …

The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank …

SD Singh, CA Rivier, K Papier, Z Chemali… - Frontiers in …, 2024 - frontiersin.org
Introduction The 21-point Brain Care Score (BCS) is a novel tool designed to motivate
individuals and care providers to take action to reduce the risk of stroke and dementia by …

Dementia risk in patients with heart disease and depression

D Denisenko, G Ekong, H Spotts - Dementia & Neuropsychologia, 2023 - SciELO Brasil
The high prevalence of Alzheimer's disease and dementia is a growing concern for
healthcare systems and patients. Objective: The primary objective of our study was to assess …

Depressive Symptomatology as a Predictor of Cognitive Impairment: Evidence from the Korean Longitudinal Study of Aging (KLOSA), 2006–2020

SU Baek, JH Yoon - Biomedicines, 2023 - mdpi.com
Depressive symptoms are recognized as risk factors for cognitive impairment with intricate
underlying biological mechanisms. We explored the link between depressive symptoms and …