The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder
KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …
Dementia and depression: biological connections with amyloid β protein
HM Dos Santos, AG Bertollo… - Basic & Clinical …, 2024 - Wiley Online Library
Dementia is an umbrella term for a broad group of age‐associated neurodegenerative
diseases. It is estimated that dementia affects 50 million people worldwide and that …
diseases. It is estimated that dementia affects 50 million people worldwide and that …
Depression and cognition are associated with lipid dysregulation in both a multigenerational study of depression and the National Health and Nutrition Examination …
SMA Mehdi, AP Costa, C Svob, L Pan… - Translational …, 2024 - nature.com
Chronic dysregulation of peripheral lipids has been found to be associated with depression
and cognition, but their interaction has not been investigated. Growing evidence has …
and cognition, but their interaction has not been investigated. Growing evidence has …
Indoleamine 2, 3-dioxygenase as a therapeutic target for Alzheimer's disease and geriatric depression
K Savonije, A Meek, DF Weaver - Brain Sciences, 2023 - mdpi.com
Neuroimmune-triggered neuroinflammation of the central nervous system is emerging as an
important aetiopathogenic factor for multiple neurological disorders, including depression …
important aetiopathogenic factor for multiple neurological disorders, including depression …
c-Diadem: a constrained dual-input deep learning model to identify novel biomarkers in Alzheimer's disease
S Jemimah, A AlShehhi… - BMC Medical …, 2023 - Springer
Background Alzheimer's disease (AD) is an incurable, debilitating neurodegenerative
disorder. Current biomarkers for AD diagnosis require expensive neuroimaging or invasive …
disorder. Current biomarkers for AD diagnosis require expensive neuroimaging or invasive …
The A-to-Z factors associated with cognitive impairment. Results of the DeCo study
M Gil-Peinado, M Alacreu, H Ramos… - Frontiers in …, 2023 - frontiersin.org
Introduction Cognitive impairment (CI) is known to be mediated by several risk and
protective factors, many of which are potentially modifiable. Therefore, it is important to have …
protective factors, many of which are potentially modifiable. Therefore, it is important to have …
The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank …
Introduction The 21-point Brain Care Score (BCS) is a novel tool designed to motivate
individuals and care providers to take action to reduce the risk of stroke and dementia by …
individuals and care providers to take action to reduce the risk of stroke and dementia by …
Dementia risk in patients with heart disease and depression
The high prevalence of Alzheimer's disease and dementia is a growing concern for
healthcare systems and patients. Objective: The primary objective of our study was to assess …
healthcare systems and patients. Objective: The primary objective of our study was to assess …
Depressive Symptomatology as a Predictor of Cognitive Impairment: Evidence from the Korean Longitudinal Study of Aging (KLOSA), 2006–2020
Depressive symptoms are recognized as risk factors for cognitive impairment with intricate
underlying biological mechanisms. We explored the link between depressive symptoms and …
underlying biological mechanisms. We explored the link between depressive symptoms and …